diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
index 50274604..bf4bbc10 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
@@ -183,7 +183,7 @@ void PipelineCache::RefreshGraphicsKey() {
     int remapped_cb{};
     for (auto cb = 0u; cb < Liverpool::NumColorBuffers; ++cb) {
         auto const& col_buf = regs.color_buffers[cb];
-        if (!col_buf || skip_cb_binding) {
+        if (skip_cb_binding || !col_buf || !regs.color_target_mask.GetMask(cb)) {
             continue;
         }
         const auto base_format =
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.cpp b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
index f7059f17..997fcead 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.cpp
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
@@ -106,6 +106,12 @@ void Rasterizer::BeginRendering() {
             continue;
         }
 
+        // If the color buffer is still bound but rendering to it is disabled by the target mask,
+        // we need to prevent the render area from being affected by unbound render target extents.
+        if (!regs.color_target_mask.GetMask(col_buf_id)) {
+            continue;
+        }
+
         const auto& hint = liverpool->last_cb_extent[col_buf_id];
         const auto& image_view = texture_cache.RenderTarget(col_buf, hint);
         const auto& image = texture_cache.GetImage(image_view.image_id);